Triterpenoid compounds from Ganoderma lucidum have a marked anti-androgen effect, inhibiting 5alpha-reductase and significantly reducing testosterone induced growth of the of the ventral prostate in rats1-4. Crude extracts from Grifola frondosa have also been reported as inhibiting androgenstimulated cell division in prostatic tissue in vivo at a dose of 500mg/kg but purification of the polysaccharides did not result in greater levels of inhibition suggesting that the active component is not polysaccharide based or only partially polysaccharide based. 1. Anti-androgenic activities of Ganoderma lucidum. Fujita R, Liu J, Shimizu K, Konishi F, Noda K, Kumamoto S, Ueda C, Tajiri H, Kaneko S, Suimi Y, Kondo R. J Ethnopharmacol. 2005;102(1):107-12.
2. The anti-androgen effect of ganoderol B isolated from the
fruiting body of Ganoderma lucidum. Liu J, Shimizu K,
Konishi F, Kumamoto S, Kondo R. Bioorg Med Chem.
3. Structure-activity relationship for inhibition of 5alphareductase
by triterpenoids isolated from Ganoderma lucidum.
Liu J, Kurashiki K, Shimizu K, Kondo R. Bioorg Med Chem.
4. 5alpha-reductase inhibitory effect of triterpenoids isolated
from Ganoderma lucidum. Liu J, Kurashiki K, Shimizu K,
Kondo R. Biol Pharm Bull. 2006;29(2):392-5.