BPH (Benign Prostatic Hyperplasia)

Triterpenoid compounds from Ganoderma lucidum have a marked anti-androgen effect, inhibiting 5alpha-reductase and significantly reducing testosterone induced growth of the of the ventral prostate in rats1-4.

Crude extracts from Grifola frondosa have also been reported as inhibiting androgenstimulated cell division in prostatic tissue in vivo at a dose of 500mg/kg but purification of the polysaccharides did not result in greater levels of inhibition suggesting that the active component is not polysaccharide based or only partially polysaccharide based.

1. Anti-androgenic activities of Ganoderma lucidum. Fujita R, Liu J, Shimizu K, Konishi F, Noda K, Kumamoto S, Ueda C, Tajiri H, Kaneko S, Suimi Y, Kondo R. J Ethnopharmacol. 2005;102(1):107-12.
2. The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum. Liu J, Shimizu K, Konishi F, Kumamoto S, Kondo R. Bioorg Med Chem. 2007;15(14):4966-72.
3. Structure-activity relationship for inhibition of 5alphareductase by triterpenoids isolated from Ganoderma lucidum. Liu J, Kurashiki K, Shimizu K, Kondo R. Bioorg Med Chem. 2006;14(24):8654-60.
4. 5alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum. Liu J, Kurashiki K, Shimizu K, Kondo R. Biol Pharm Bull. 2006;29(2):392-5.

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