Category Archives: Health Conditions

 

Nerve Damage

Daily administration of aqueous extract of Hericium erinaceous fresh fruitbodies showed a beneficial effect on the recovery of injured rat peroneal nerve in the early stages of regeneration with faster recovery in the treated group than in the untreated group1. G. lucidum spores have also shown beneficial activity in a...
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Liver Damage

In a study on 14 patients with alcohol induced liver steatosis supplementation with Cordyceps sinensis biomass at 3g/day resulted in a 70% reduction in AST, a 63% reduction in ALT and a 64% reduction in GGT over a 90 day period1. Animal studies also show that C. sinensis can inhibit...
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Infertility

Cordyceps sinensis has a traditional history of use in the treatment of both male and female infertility and in vitro studies have shown it to stimulate production of sex hormones through activation of both the protein kinase A and protein kinase C signal transduction pathways1. As these pathways are activated...
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High Blood Pressure

Ganoderma lucidum has traditionally been used in the treatment of hypertension1 and ACE inhibitory activity has been demonstrated for the triterpene Ganoderic acid K2. It has also been suggested that the CNS inhibiting action of triterpenes from G. lucidum may play a part in its anti-hypertensive actions of this mushroom3....
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High Cholesterol

Because of their high fibre content, sterols and low calorific value mushrooms are an ideal food for diets designed to prevent cardiovascular disease and have also been extensively investigated for their potential therapeutic application in this regard. In animal models a range of mushrooms, including Agaricus bisporus (common button mushroom),...
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HPV

In a trial using Coriolus versicolor biomass (3g/day) 9 of 10 women with high risk strains of HPV had cleared them after 1 year, while only 1 of 12 women in a control group had. Also 13 of 18 patients still showed normal cervical cytology after 1 year compared to...
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HIV

The nucleoside derivatives found in Cordyceps sinensis, including cordycepin (3’-deoxyadenosine), are reverse transcriptase inhibitors of the type now being used to treat HIV and in vitro studies confirm them to be effective in inhibiting HIV replication1-3. The proteoglycans PSK and PSP from C. versicolor have also been shown to be...
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Diabetes

Fungal beta glucans, along with beta glucans from oats and barley, have been shown to help control blood glucose levels and it has been suggested that a possible mechanism is activation of P13K/Akt through binding to receptors including Dectin 1 and scavenger receptors1. However, daily supplementation of a normal diet...
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Hepatitis

Several polysaccharide extracts have shown benefit in treatment of hepatitis B. Concentrated polysaccharide extracts from Polyporus umbellatus (92% polysaccharide) are used in China to treat patients with chronic HBV (40mg/day) with significant beneficial effect on clearing serum HBsAg and hepatitis B virus (HBV) DNA69,70, while a small study with A....
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Chronic Fatigue

CFS patients show immune dysfunction, including low NK cell activity, and the condition has also been linked to high viral counts, especially Epstein-barr virus (EBV). Recent research confirms the elevated levels of Th2 cytokines in patients with CFS and prevailing Th2 inflammatory milieu, together with highly attenuated Th1 immune response1-3....
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Candidiasis / Thrush

Mushrooms are seen to exhibit both direct and indirect anti-fungal activity in-vitro and in-vivo1. The widely held belief that mushrooms somehow exacerbate candidal overgrowth runs contrary to scientific research, clinical experience and theoretical understanding. Not only do mushrooms stimulate the bodies anti-fungal immune response but in nature they need to...
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BPH (Benign Prostatic Hyperplasia)

Triterpenoid compounds from Ganoderma lucidum have a marked anti-androgen effect, inhibiting 5alpha-reductase and significantly reducing testosterone induced growth of the of the ventral prostate in rats1-4. Crude extracts from Grifola frondosa have also been reported as inhibiting androgenstimulated cell division in prostatic tissue in vivo at a dose of 500mg/kg...
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Asthma

Cordyceps sinensis has traditionally been used to treat respiratory disorders including asthma and serum markers of airway inflammation were seen to be reduced in patients with mild asthma given C. sinensis capsules1. C. sinensis also improved lung function in sensitized guinea pigs and reduce airway inflammation in sensitized rats2. In...
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Alzheimers Disease

Low levels of nerve growth factor (NGF) are also seen in AD with implications for the application of Hericium erinaceous in the management of this condition (see discussion on Dementia). In addition, synaptic degeneration, with loss of synaptic density proteins, has been shown to be a key mode of neurodegeneration...
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Hayfever

Ganoderma lucidum shows excellent results in the management of allergic rhinitis, its polysaccharides suppressing the pro-inflammatory, Th2 mediated immune state responsible for the hypersensitivity to the particular allergen(s) while several of its triterpenoid ganoderic and lucidenic acids have direct anti-inflammatory and anti-histamine action1-4. It thus addresses both the symptoms and...
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Liver Cancer

Nanba et al reported that 7 of 12 patients with liver cancer responded to a combination of Grifola frondosa fruiting body (4-6g/day) and purified polysaccharide extract (MD fraction – 40-150mg/day),1. Studies using implanted sarcoma 180 as a model for liver cancer have shown inhibition of tumour rates of 52.8%, 56.6%...
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Colorectal Cancer

A recent meta-analysis of 3 clinical trials in Japan with 1,094 patients showed clear benefit from PSK supplementation (3.0g/day) in improving both survival and disease-free survival in cases of curatively resected colorectal cancer1,2. Chihara et al also report excellent results from a 4 year follow-up of Lentinan in phase III...
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Cervical Cancer

Schizophyllan (Sizofiran), a polysaccharide extract of Schizophyllan commune, is licensed in Japan for the treatment of cervical cancer and, in a 5-year multi-centre study, has been shown to significantly extend time to recurrence and improve survival rates in patients with stage II cervical cancer but not in those with stage...
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Lung Cancer

Trametes versicolor polysaccharide extracts show impressive benefits in cases of lung cancer. In a 1993 study on patients with stage I-III non-small cell lung cancer treated with radiotherapy and PSK, PSK extended 5-yr survival 2-4x for all stages with maximum benefit in patients over the age of 70 and for...
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Prostate Cancer

Ganoderma lucidum has been identified as a promising agent for prostate cancer with in vitro evidence showing inhibition of hormone dependent and independent prostate cancer cells through multiple pathways, including binding to androgen receptor, inhibition of the active transcription factors: NF-kB and AP-1, inhibition of urokinase-type plasminogen activator (uPA) and...
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