CFS patients show immune dysfunction, including low NK cell activity, and the condition has also been linked to high viral counts, especially Epstein-barr virus (EBV). Recent research confirms the elevated levels of Th2 cytokines in patients with CFS and prevailing Th2 inflammatory milieu, together with highly attenuated Th1 immune response1-3. The proven ability of mushroom nutrition to promote a shift away from a Th2 dominant immune response and increase anti-viral activity makes it a natural source of support for patients with CFS with good results, including an ability to increase NK Cell activity in CFS patients and also improve lifestyle scores, with Trametes versicolor biomass supplementation producing a 35% increase in NK cell activity in mild CFS at a dose of 1.5-3g/day (more severe cases are reported to respond to higher dosages)4. 33. A formal analysis of cytokine networks in Chronic Fatigue Syndrome. Broderick G, Fuite J, Kreitz A, Vernon S.D, Klimas N, Fletcher M.A. Brain Behav Immun. 2010. [Epub ahead of print]
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