Compounds in Hericium erinaceous are able to stimulate the production of nerve growth factor (NGF), which promotes repair and regeneration of neurons, and there is growing clinical evidence showing benefit for H. erinaceous in cases of mild dementia. In a double blind placebo controlled trial on 50-80-year old Japanese men and women with mild cognitive impairment given 3g/day as tablets showed showed significant increases on a cognitive function scale compared with the placebo group over a 16 week period1. In another study 7 patients with different types of dementia were given 5g a day of H. erinaceous in soup. After six months all seven demonstrated improvement in their Functional Independence Measure score (eating, dressing, walking, etc.), while six out of seven demonstrated improvements in their perceptual capacities (understanding, communication, memory, etc.)2. 1. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Phytother Res. 2009;23(3):367-72.
2. The anti-Dementia effect of Lion’s mane mushroom and its
clinical application. Kawagishi H, Zhuang C, Shnidman E.
Townsend Letter for Doctors and Patients. April, 2004 Epub.