High Blood Pressure

Ganoderma lucidum has traditionally been used in the treatment of hypertension1 and ACE inhibitory activity has been demonstrated for the triterpene Ganoderic acid K2. It has also been suggested that the CNS inhibiting action of triterpenes from G. lucidum may play a part in its anti-hypertensive actions of this mushroom3.

In the light of recent data, which suggests that subsets of T lymphocytes play critical roles in the development of angiotensin II, deoxycorticosterone salt-sensitive and Dahl saltsensitive hypertension, and in the progression of vascular remodeling, it is possible that mushrooms may have a beneficial effect on blood pressure by virtue of their immune regulating properties4.

However, beneficial effects for other mushrooms have only been demonstrated at unrealistic dietary levels of between 5-20%5-7, or in the case of Agaricus brasiliensis, with a GABA-enriched extract8.

1. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). Kabir Y, Kimura S, Tamura T. J Nutr Sci Vitaminol (Tokyo). 1988;34(4):433-8.
2. Effect of Ganoderma lucidum on the quality and functionality of Korean traditional rice wine, yakju. Kim J.H, Lee D.H, Lee S.H, Choi S.Y, Lee J.S. J Biosci Bioeng. 2004;97(1):24-8.
3. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Lee S.Y, Rhee H.M. Chem Pharm Bull (Tokyo). 1990;38(5):1359-64.
4. T lymphocytes: a role in hypertension? Schiffrin E.L. Curr Opin Nephrol Hypertens. 2010;19(2):181-6.
5. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. Kabir Y, Yamaguchi M, Kimura S. J Nutr Sci Vitaminol (Tokyo). 1987;33(5):341-6.
6. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Talpur N.A, Echard B.W, Fan A.Y, Jaffari O, Bagchi D, Preuss H.G. Mol Cell Biochem. 2002;237(1-2):129-36.3.
7. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). Kabir Y, Kimura S. J Nutr Sci Vitaminol (Tokyo). 1989;35(1):91-4.
8.Watanabe T, Kawashita A, Ishi S, Mazumder T.K, Nagai S, Tsuji K, Dan T. Antihypertensive effect of γ-aminobutyric acid-enriched Agaricus blazei on mild hypertensive human subjects. Nippon Shokuhin Kagaku Kogaku Kaishi. 2003;50(4):167-173

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