The nucleoside derivatives found in Cordyceps sinensis, including cordycepin (3’-deoxyadenosine), are reverse transcriptase inhibitors of the type now being used to treat HIV and in vitro studies confirm them to be effective in inhibiting HIV replication1-3. The proteoglycans PSK and PSP from C. versicolor have also been shown to be capable of inhibiting both HIV-1 reverse transcriptase and protease, two key enzymes in the life cycle of HIV4-6, as have triterpenes from Ganoderma lucidum, which also inhibit NF-kappaB expression and viral binding7,8. In addition there is in-vitro evidence that betulinic acid analogs (present in I. obliquus) disrupt HIV fusion to the cell membrane in a post-binding step through interaction with the viral glycoprotein gp41 as well as disrupting assembly and budding of the HIV-1 virus9,10. Coriolus biomass supplementation (3g/day) given as part of traditional Chinese medicine treatment for patients with HIV produced improvements in CD4 count and reductions in viral load as well as fading of the Kaposi’s sarcoma (caused by human herpes virus 8) in AIDS patients11,12. 1. Emerging antiviral drugs from medicinal mushrooms. Pirano F.F. Int J Med Mushr. 2006;8(2):20
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Pfeiffer M. Presented at the III International Symposium on
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