Daily administration of aqueous extract of Hericium erinaceous fresh fruitbodies showed a beneficial effect on the recovery of injured rat peroneal nerve in the early stages of regeneration with faster recovery in the treated group than in the untreated group1. G. lucidum spores have also shown beneficial activity in a mouse nerve damage model with increased expression of collapsin response mediator protein 2 (CRMP-2), isocitrate dehydrogenase [NAD] subunit beta (IDH-beta), ATPase and glutamate oxaloacetate transaminase-1 (GOT1) and lower expression levels of F-actin capping protein beta subunit (FCP-beta) and M2 pyruvate kinase (M2-PK)2. 1. Functional recovery enhancement following injury to rodent peroneal nerve by Lion’s Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae). Wong K.H, Naidu M, David R.P, Abdulla M.A, Abdullah N, Kuppusamy U.R, Sabaratnam V. Int J Med Mushr. 2009;11(3):20
2. Primary study on proteomics about Ganoderma lucidium
spores promoting survival and axon regeneration of injured
spinal motor neurons in rats. Zhang W, Zeng Y.S, Wang Y,
Liu W, Cheng J.J, Chen S.J. Zhong Xi Yi Jie He Xue Bao.